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Abstract:

Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent cell layer to study the role of activity in cell sorting. We find that a mixture of cells with extensile or contractile dipolar activity, and which are identical apart from their activity, quickly sort into small, elongated patches which then grow slowly in time. We interpret the sorting as driven by the different diffusivity of the extensile and contractile cells, mirroring the ordering of Brownian particles connected to different hot and cold thermostats. We check that the free energy is not changed by either partial or complete sorting, thus confirming that activity can be responsible for the ordering even in the absence of thermodynamic mechanisms.

Abstract:

We initiate the study of the classical mechanics of nonrelativistic fractons in its simplest setting—that of identical one-dimensional particles with local Hamiltonians characterized by a conserved dipole moment in addition to the usual symmetries of space and time translation invariance. We introduce a family of models and study the N -body problem for them. We find that locality leads to a “Machian” dynamics in which a given particle exhibits finite inertia only if within a specified distance of another particle. For well-separated particles, this dynamics leads to immobility, much as for quantum models of fractons discussed before. For two or more particles within inertial reach of each other at the start of motion, we obtain an interesting interplay of inertia and interactions. Specifically, for a solvable “inertia only” model of fractons, we find that two particles always become immobile at long times. Remarkably, three particles generically evolve to a late time state with one immobile particle and two oscillating about a common center of mass with generalizations of such “Machian clusters” for N>3. Interestingly, these Machian clusters exhibit physical limit cycles in a Hamiltonian system even though mathematical limit cycles are forbidden by Liouville's theorem.